said 1 year, 4 months ago:
I always setup comments with moderation by default.
Akismet and Captcha do a nice job, but there are still ways for spam to slip thru. And you can still get comments that do not belong to your post (be it an offensive remark by some anonymous bored surfer, or a totally unrelated, private and slightly embarrassing question by a family member…).
I believe that since it’s your (company’s) blog, you are allowed to make sure the quality of the content is on a certain level.
Also, when you moderate comments, you pay closer attention to what is said, and you are more likely to respond to them.